Molecular Basis of Vancomycin Dependence in VanA-Type Staphylococcus aureus VRSA-9
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چکیده
منابع مشابه
VanA-type Staphylococcus aureus strain VRSA-7 is partially dependent on vancomycin for growth.
VanA-type Staphylococcus aureus strain VRSA-7 was partially dependent on glycopeptides for growth. The vanA gene cluster, together with the erm(A) and the ant(9)-Ia resistance genes, was carried by the ca. 35- to 40-kb conjugative plasmid pIP848 present at five copies per cell. The chromosomal ddl gene had a mutation that led to a N308K substitution in the d-Ala:d-Ala ligase that resulted in a ...
متن کاملVanA-type vancomycin-resistant Staphylococcus aureus.
Since 2002, nine methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) strains that are also resistant to vancomycin (VRSA) have been reported in the United States, including seven clinical isolates from Michigan. The strains harbor a plasmid-borne Tn1546 element following conjugation from a glycopeptide-resistant Enterococcus strain. In the second step, Tn1546 transposed to a residen...
متن کاملEmergence of Vancomycin-Resistant Staphylococcus Aureus (VRSA)
Background: Staphylococcus aureus is one of the bacteria under the genus Staphylococcus which is a gram-positive coccus. It is microscopically observed as individual organisms, in pairs and in irregular, grapelike clusters. S. aureus is non-motile and non-spore forming bacteria. It is one of the most common community and nosocomial pathogen. It mainly causes skin and soft tissue infections as i...
متن کاملRevised manuscript AAC00346-09 VanA-type vancomycin-resistant Staphylococcus aureus
2 Staphylococcus aureus is one of the most common causes of hospital-and community-acquired infections and treatment of staphylococcal infections is complicated by the ability of this bacterial species to become resistant to antibiotics. Vancomycin is the drug of choice for therapy of infections due to methicillin-resistant S. aureus (MRSA) but increase in vancomycin use has led to the emergenc...
متن کاملStaphylococcus aureus VRSA-11B is a constitutive vancomycin-resistant mutant of vancomycin-dependent VRSA-11A.
Vancomycin-resistant Staphylococcus aureus VRSA-10 was isolated in 2009, whereas VRSA-11A and VRSA-11B were isolated from the same patient in 2010. Growth curves and determination of the nature of the peptidoglycan precursors and of the VanX d,d-dipeptidase activity in the absence and in the presence of vancomycin indicated that vancomycin resistance was inducible in VRSA-10, that VRSA-11A was ...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2010
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00613-10